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Produktbild: Retinal Gene Therapy
Band 1715

Retinal Gene Therapy Methods and Protocols

Aus der Reihe Methods in Molecular Biology

Fr. 202.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

29.11.2017

Abbildungen

XVI, 54 illus., 44 illus. in color., schwarz-weiss Illustrationen, farbige Illustrationen

Herausgeber

Camiel J.F. Boon + weitere

Verlag

Springer Us

Seitenzahl

380

Maße (L/B/H)

26/18.3/2.7 cm

Gewicht

954 g

Auflage

1st ed.

Sprache

Englisch

ISBN

978-1-4939-7521-1

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

29.11.2017

Abbildungen

XVI, 54 illus., 44 illus. in color., schwarz-weiss Illustrationen, farbige Illustrationen

Herausgeber

Verlag

Springer Us

Seitenzahl

380

Maße (L/B/H)

26/18.3/2.7 cm

Gewicht

954 g

Auflage

1st ed.

Sprache

Englisch

ISBN

978-1-4939-7521-1

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Retinal Gene Therapy

  • Part I: Retinal Gene Therapy Vector Production and Biological Assays In Vitro

     

    1. Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System

                Joost Verhaagen, Barbara Hobo, Erich M.E. Ehlert, Ruben Eggers, Joanna A. Korecka, Stefan A. Hoyng, Callan L. Attwell, Alan R. Harvey, and Matthew R.J. Mason

     

    2. Small and Micro-Scale Recombinant Adeno-Associated Virus Production and Purification for Ocular Gene Therapy Applications

                Christopher A. Reid and Daniel M. Lipinski

     

    3. Design and Development of AAV-Based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa

                Christian Schön, Elvir Becirovic, Martin Biel, and Stylianos Michalakis

     

    4. Development of Multigenic Lentiviral Vectors for Cell-Specific Expression of Antiangiogenic miRNAs and Protein Factors

                Anne Louise Askou and Thomas J. Corydon

     

    5. Design and In Vitro Use of Antisense Oligonucleotides to Correct Pre-mRNA Splicing Defects in Inherited Retinal Dystrophies

                Alejandro Garanto and Rob W.J. Collin

     

    6. Three-Dimensional Co-Culture Bioassay for Screening of Retinal Gene Delivery Systems

                Ding Wen Chen, Kathleen Pauloff, and Marianna Foldvari

     

    7. Retinal Gene Therapy for Choroideremia: In Vitro Testing for Gene Augmentation Using an Adeno-Associated Viral (AAV) Vector

                Maria I. Patrício and Robert E. MacLaren

     

    Part II: Assays for Gene Augmentation and Editing In Vivo on Rodent and Macaque Retina

     

    8. In Vivo Electroporation of Developing Mouse Retina

                Jimmy de Melo and Seth Blackshaw

     

    9. Methods for In Vivo CRISPR/Cas Editing of the Adult Murine Retina

                Sandy S. Hung, Fan Li, Jiang-Hui Wang, Anna E. King, Bang V. Bui, Guei-Sheung Liu, and Alex W. Hewitt

     

    10. AAV Gene Augmentation Therapy for CRB1-Associated Retinitis Pigmentosa

                C. Henrique Alves and Jan Wijnholds

     

    11. Dual AAV Vectors for Stargardt Disease

                Ivana Trapani

     

    12. Optogenetic Retinal Gene Therapy with the Light Gated GPCR Vertebrate Rhodopsin

                Benjamin M. Gaub, Michael H. Berry, Meike Visel, Amy Holt, Ehud Y. Isacoff, and John G. Flannery

     

    13. CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa: A Brief Methodology

                Wen-Hsuan Wu, Yi-Ting Tsai, Sally Justus, Galaxy Y Cho, Jesse D Sengillo, Yu Xu, Thiago Cabral, Chyuan-Sheng Lin, Alexander G. Bassuk, Vinit B. Mahajan, and Stephen H. Tsang

     

    14. In-Depth Functional Analysis of Rodents by Full-Field Electroretinography

                Vithiyanjali Sothilingam, Regine Mühlfriedel, Naoyuki Tanimoto, and Mathias W. Seeliger

     

    15. Advanced Ocular Injection Techniques for Therapy Approaches

                Regine Mühlfriedel, Marina Garcia Garrido, Christine Wallrapp, and Mathias W. Seeliger

     

    16. Neutralizing Antibodies Against Adeno-Associated Virus (AAV): Measurement and Influence on Retinal Gene Delivery

                Mélissa Desrosiers and Deniz Dalkara

     

    17. Screening for Neutralizing Antibodies against Natural and Engineered AAV Capsids in Non-Human Primate Retinas

                Timothy P. Day, Leah C. Byrne, John G. Flannery, and David V. Schaffer

     

    18. Subretinal and Intravitreal Retinal Injections in Monkeys

                Daniyar Dauletbekov, K. Ulrich Bartz-Schmidt, and M. Dominik Fischer

     

    Part III: Clinical Protocols and Retinal Gene Therapy Vector Testing on Human Retina

     

    19. Production of iPS-derived Human Retinal Organoids for Use in Transgene Expression Assays

                Peter M. Quinn, Thilo M. Buck, Charlotte Ohonin, Harald Mikkers, and Jan Wijnholds

     

    20. AAV Serotype Testing on Cultured Human Donor Retinal Explants

                Thilo M. Buck, Lucie P. Pellissier, Rogier M. Vos, Elon H.C. van Dijk, Camiel J.F. Boon, and Jan Wijnholds

     

    21. Human Retinal Explant Culture for Ex-Vivo Validation of AAV Gene Therapy

                Harry O. Orlans, Thomas L. Edwards, Samantha R. De Silva, Maria I. Patrício, and Robert E. MacLaren

     

    22. Visual Acuity Testing Before and After Intravitreal Injection of rAAV2- ND4 in Patients

                Bin Li and Chenmian Wu

     

    23. Recording and Analysis of the Human Clinical Electroretinogram

                Mathieu Gauvin, Allison L. Dorfman, and Pierre Lachapelle

     

    24. Recording and Analysis of Goldmann Kinetic Visual Fields

                Mays Talib, Gislin Dagnelie, and Camiel J.F. Boon

     

    25. Measuring Central Retinal Sensitivity Using Microperimetry

                Mays Talib, Jasleen K. Jolly, and Camiel J.F. Boon

     

    26. Inspection of the Human Retina by Optical Coherence Tomography

                Thomas Theelen and Michel M. Teussink

     

    27. Vector Shedding and Immunogenicity Sampling for Retinal Gene Therapy

                Alun R. Barnard, Anna N. Rudenko, and Robert E. MacLaren