Produktbild: Dwevedi, a: Disease Proteomics

Dwevedi, a: Disease Proteomics An Effectual Tool in Disease Diagnostics and Therapeutics

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

10.12.2020

Verlag

John Wiley & Sons Inc

Seitenzahl

250

Gewicht

666 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-50319-4

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

10.12.2020

Verlag

John Wiley & Sons Inc

Seitenzahl

250

Gewicht

666 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-50319-4

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  • Produktbild: Dwevedi, a: Disease Proteomics
  • Preface

    CHAPTER 1 ADVANCEMENT IN THE TECHNOLOGY OF PROTEOMICS AND ITS APPLICATIONS IN MEDICINE

    Introduction

    Characteristic Features Of Disease Biomarker For Diagnostics

    Schematic biomarker selection

    Effects of sample type on biomarker selection

    Expert commentary

    Key issues

    Five year view

    Protein As Biomarker In Disease Diagnostics

    Overview On The Technology Of Proteomics

    Mining

    Protein expression profiling

    Protein network mapping

    Mapping of protein modifications

    Overview On Mass Spectrometry

    Technical details of mass spectrometer

    Tandem MS

    CHAPTER 2 IMPLICATION OF PROTEOMICS IN THE IDENTIFICATION OF DISEASE SPECIFIC PROTEIN BIOMARKERS

    Introduction

    Sequential Steps In Disease Diagnostics Through Proteomics

    Requirements of an ideal biomarker

    Biomarker sources

    Addressing the problem of high abundance proteins

    Mining of plasma glycoproteins

    Basic proteomics steps for biomarker identification

    Role of proteomics in biomarker candidates' verification

    Proteomics in the Identification of Disease Biomarkers

    4. Proteomics in the Development of Precision Medicine

    4.1.Factors affecting individual drug response

    4.2.Proteomics in sequential stages of drug development

    4.3.Assessment of precision medicine by toxicoproteomics

    5. Challenges In Clinical Adoption Of Disease Proteomics

    5.1. Challenges during preclinical and clinical phases

    5.2.Barriers in clinical adoption

    6. Future Outlook And Conclusions

    CHAPTER 3 CIRCUMSPECTION OF CURRENT PROTEOMICS TECHNOLOGY

    Introduction

    Technological Impedance In Disease Proteomics

    Two dimensional electrophoresis (2DE)

    Fluorescence 2D difference gel electrophoresis (2D-DIGE)

    Isotope-coded affinity tag (ICAT)

    Stable isotope labeling with amino acids in cell culture (SILAC)

    18O Stable isotope labeling

    Isobaric tag for relative and absolute quantitation (iTRAQ)

    Large-scale western blotting proteome analysis

    Multidimensional protein identification technology (MudPIT)

    Key Impedance In Disease Proteomics

    Serum proteomics and biomarker Discovery

    Membrane proteome

    Overview On Recent Technological Advancements In Proteomics Methods For Protein Identification And Biomarker Discovery

    Two dimensional (2D) electrophoresis in proteomics

    Mass spectrometry (MS)

    Protein identification via bioinformatics

    Organelle proteomics and sub-cellular fractionation

    Post-translational modification analysis (PTM)

    Proteome analysis of un-sequenced/non-model organisms

    Conclusions

    CHAPTER 4 PROTEOMICS AND SYSTEM BIOLOGY: CORRELATION FOR EFFECTIVE, PREVENTATIVE AND PERSONALIZED MEDICINE

    Introduction

    System Biology In Clinical Proteomics

    Correlating systems biology with medicine

    Elucidation of cellular disease networks via system biology

    Connecting proteomics with systems biology

    Proteomics Is The Basis Of System Biology

    3.1.Key features of proteomics

    3.2.Proteomics achievements: Provide the foundation of system biology

    3.3.Further advances in proteomics

    Insight Into Disease Interactome

    4.1.Steps in making disease interactome

    5. Network Medicine: Applying Network-Based Knowledge In Disease Diagnostics And Therapeautics

    Key notes on network medicine

    Multidisciplinary and communication

    Ethical considerations in systems medicine

    Conclusions

    References

    Index