Some 4-Thiazolidinones as Antimicrobial Agents 4-Thiazolidinones: Antimicrobial Agents
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- Englisch ausgewählt
Fr. 51.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
20.11.2017
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
72
Maße (L/B/H)
22/15/0.5 cm
Gewicht
125 g
Sprache
Englisch
ISBN
978-3-659-68637-5
4-Thiazolidinones are derivatives of thiazolidine with a carbonyl group at the 4-position, substitutents in the 2-, 3-, and 5-positions may be varied, but greatest differences in structure and properties is exerted by the group attached to the carbon atom in 2-position. Syntheses of 4-thiazolidinones are three component reactions involving an amine, a carbonyl compound and a mercaptoacetic acid.The process can be one pot condensation reaction. The reaction has been suggested to proceed via imine formation followed by attack of sulfur nucleophile on imine carbon. The last step involves intramolecular cyclization with the elimination of water to give 4-thiazolidinone. These derivatives are known to exhibit diverse biological activities like anticonvulsant, antidiarrheal, anti-platelet, antihistaminic, antimicrobial, antiviral, antidiabetic, anti-inflammatory, analgesic etc.
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