Produktbild: Essential Developmental Biology

Essential Developmental Biology

Fr. 173.00

inkl. gesetzl. MwSt., Versandkostenfrei


Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

16.12.2021

Verlag

John Wiley & Sons Inc

Seitenzahl

544

Maße (L/B/H)

27.5/21.5/2.8 cm

Gewicht

1532 g

Auflage

4. Auflage

Sprache

Englisch

ISBN

978-1-119-51285-1

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

16.12.2021

Verlag

John Wiley & Sons Inc

Seitenzahl

544

Maße (L/B/H)

27.5/21.5/2.8 cm

Gewicht

1532 g

Auflage

4. Auflage

Sprache

Englisch

ISBN

978-1-119-51285-1

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

Noch keine Bewertungen vorhanden

Verfassen Sie die erste Bewertung zu diesem Artikel

Helfen Sie anderen Kundinnen und Kunden durch Ihre Meinung.

Kundinnen und Kunden meinen

Bewertungen (0)

Die Leseprobe wird geladen.
  • Produktbild: Essential Developmental Biology
  • Preface, ix

    About the companion website, xi

    Section 1: Groundwork, 1

    1 The excitement of developmental biology, 3

    Where the subject came from, 3

    Impact of developmental biology, 4

    Future impact, 5

    2 How development works, 7

    Ultrashort summary, 7

    Gametogenesis, 10

    Early development, 13

    Growth and death, 19

    3 Approaches to development: developmental genetics, 25

    Developmental mutants, 25

    Sex chromosomes, 27

    Maternal and zygotic, 27

    Genetic pathways, 28

    Genetic mosaics, 30

    Screening for mutants, 31

    Cloning of genes, 32

    Gain-and loss-of-function experiments, 32

    Transgenesis, 32

    Other gain-of- function techniques, 34

    Targeted mutagenesis, 34

    Other loss-of- function systems, 35

    Gene duplication, 36

    Limitations of developmental genetics, 37

    4 Approaches to development: experimental embryology and its molecular basis, 39

    Normal development, 39

    Developmental commitment, 42

    Criteria for proof, 48

    Transcription factors, 48

    Transcription factor families, 50

    Other controls of gene activity, 51

    Signaling systems, 51

    Genetic regulatory networks, 57

    5 Approaches to development: cell and molecular biology techniques, 61

    Microscopy, 61

    Optical techniques, 61

    Confocal, multi-photon, and light sheet microscopes, 63

    Image capture, 63

    Anatomical and histological methods, 64

    Microinjection, 66

    Study of gene expression by molecular biology methods, 67

    Study of gene expression by in situ methods, 72

    Reporter genes, 75

    Cell-labeling methods, 76

    6 Cells into tissues, 81

    Cells in embryos, 81

    Cytoskeleton, 82

    Small GTP-binding proteins, 84

    Extracellular matrix, 84

    Cell movement, 85

    Epithelial organization, 86

    Morphogenetic processes, 88

    Section 2: Major model organisms, 97

    7 Major model organisms, 99

    The big six, 99

    Access and micromanipulation, 101

    Genetics and genomes, 101

    Relevance and tempo, 102

    Other organisms, 102

    8 Xenopus, 107

    Oogenesis, maturation, and fertilization, 108

    Normal development, 109

    Fate maps, 114

    Experimental methods, 115

    Processes of regional specification, 119

    9 The zebrafish, 135

    Normal development, 135

    Fate map, 140

    Genetics, 141

    Reverse genetic methods, 144

    Embryological techniques, 145

    Regional specification, 145

    Other roles of the zebrafish, 150

    10 The chick, 153

    Normal development, 154

    Fate map, 158

    Regional specification of the early embryo, 159

    Description of organogenesis in the chick, 164

    11 The mouse, 173

    Mammalian fertilization, 173

    Normal development of the mouse, 177

    Fate map, 184

    Regional specification in the mouse embryo, 185

    Transgenic mice, 190

    Embryonic stem cells, 192

    Knockouts and knock-ins, 192

    Nuclear transplantation and imprinting, 196

    X-inactivation, 196

    Teratocarcinoma, 198

    12 Human early development, 203

    Human reproduction, 203

    Preimplantation development, 205

    Human embryonic stem cells, 207

    Human postimplantation development, 208

    Postimplantation diagnosis: chorionic villus sampling and amniocentesis, 211

    Ethics of human development, 211

    13 Drosophila, 217

    Insects, 217

    Normal development, 219

    Fate map, 222

    Pole plasm, 224

    Drosophila developmental genetics, 224

    The developmental program, 227

    The dorsoventral pattern, 228

    The anteroposterior system, 232

    14 Caenorhabditis elegans, 247

    Adult anatomy, 248

    Embryonic development, 249

    Regional specification in the embryo, 251

    Analysis of postembryonic development, 259

    The germ line, 262

    Programmed cell death, 264

    Section 3: Organogenesis, 269

    15 Techniques for studying organogenesis and postnatal development, 271

    Genetics, 271

    Clonal analysis, 275

    Tissue and organ culture, 278

    Cell analysis and separation, 279

    16 Development of the nervous system, 283

    Overall structure and cell types, 283

    Regional specification, 286

    Neurogenesis and gliogenesis, 292

    The neural crest, 299

    Development of neuronal connectivity, 303

    17 Development of mesodermal organs, 315

    Somitogenesis, 315

    Myogenesis, 322

    The kidney, 323

    Germ cell and gonadal development, 326

    Sex determination, 330

    Limb development, 330

    Blood and blood vessels, 340

    The heart, 343

    18 Development of endodermal organs, 355

    Normal development, 355

    Organization of the gut tube, 356

    Fate map of the endoderm, 359

    Experimental analysis of endoderm development, 359

    The pancreas, 366

    19 Drosophila imaginal discs, 373

    Metamorphosis, 373

    Genetic study of larval development, 374

    Disc development, 378

    Compartments and selector genes, 378

    Regional patterning of the wing disc, 381

    Regeneration and transdetermination, 384

    Morphogen gradients and polarity, 387

    Section 4: Growth, evolution, regeneration, 391

    20 Tissue organization and stem cells, 393

    Types of tissue, 393

    Tissue renewal, 397

    Stem cells, 401

    Intestinal epithelium, 403

    Epidermis, 408

    Hair follicles, 410

    Hematopoietic system, 415

    Mesenchymal stem cells and "transdifferentiation", 419

    Spermatogonia, 419

    21 Growth, aging, and cancer, 425

    Growth: control of size and proportion, 425

    Biochemical pathways of growth control, 426

    Growth control in insects, 429

    Growth control in mammals, 431

    Liver regeneration, 433

    Growth in stature, 434

    Aging, 436

    Cell autonomous processes, 437

    The insulin pathway and aging, 438

    Caloric restriction, 438

    Cancer, 440

    Classification of tumors and precursor lesions, 440

    Molecular biology of cancer, 442

    Cancer stem cells, 443

    Cancer progression, 444

    Cancer therapy, 445

    22 Pluripotent stem cells and their applications, 449

    Human embryonic stem cells, 449

    Induced pluripotent stem cells, 451

    Somatic cell nuclear transfer, 453

    Direct reprogramming, 454

    Applications of human pluripotent stem cells, 455

    Cell transplantation therapy, 457

    Cell transplantation therapies using pluripotent stem cells, 459

    Transplantation therapy for diabetes, 460

    Retinal pigment epithelium, 462

    Spinal repair, 463

    Cardiomyocytes, 463

    Parkinson's disease, 463

    Introduction of new therapies, 465

    23 Evolution and development, 469

    Macroevolution, 470

    Molecular taxonomy, 471

    Phylogeny of animals, 472

    The fossil record, 473

    The primordial animal, 474

    Basal animals, 479

    What really happened in evolution?, 481

    Segmented body plans and Hox genes, 482

    Insect wings and legs, 483

    Atavisms, 483

    Vertebrate limbs, 485

    24 Regeneration of missing parts, 491

    Types of regeneration, 491

    Distribution of regenerative capacity, 491

    Planarian regeneration, 492

    Insect limb regeneration, 497

    Vertebrate limb regeneration, 499

    The process of limb regeneration, 499

    The source of cells for regeneration, 501

    Regeneration of regional pattern, 502

    Regeneration: ancestral or adaptive property?, 508

    General properties of regeneration, 509

    Glossary, 513

    Index, 527