Produktbild: Patient Centric Blood Sampling and Quantitative Analysis

Patient Centric Blood Sampling and Quantitative Analysis

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

31.10.2023

Herausgeber

Neil Spooner + weitere

Verlag

John Wiley & Sons Inc

Seitenzahl

400

Maße (L/B/H)

23.5/15.7/2.6 cm

Gewicht

730 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-61555-2

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

31.10.2023

Herausgeber

Verlag

John Wiley & Sons Inc

Seitenzahl

400

Maße (L/B/H)

23.5/15.7/2.6 cm

Gewicht

730 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-61555-2

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Patient Centric Blood Sampling and Quantitative Analysis
  • List of Contributors xiii
     
    Foreword xvii
     
    Preface xix
     
    1 Patient Centric Healthcare - What's Stopping Us? 1
    Jenny Royle and Rachel Jones
     
    1.1 The Evolution of Future Health Systems 1
     
    1.2 Exploring the Barriers to Home Sampling 3
     
    1.2.1 Barrier One--The Discord Between Innovation and Practice 4
     
    1.2.2 Barrier Two--Ethical and Operational Considerations 5
     
    1.2.3 Barrier Three--Where Does the Liability Sit? 7
     
    1.2.4 Barrier Four--Addressing the Technology Challenge 8
     
    1.2.5 Barrier Five--The Human Touch 9
     
    1.2.6 Barrier Six--Trust in Data Security 10
     
    1.2.7 Barrier 7--Adherence to Service Change 11
     
    1.3 Conclusion: The Changing Role of Home Sampling 12
     
    References 13
     
    2 Tips for Successful Quantitative Assay Development Using Mitra Blood Sampling with Volumetric Absorptive Microsampling 17
    James Rudge
     
    2.1 What is Volumetric Absorptive Microsampling? 17
     
    2.2 Tip 1--Ensure the Use of a Correct Sampling Procedure to Prevent Volume-Related Biases 18
     
    2.3 Tip 2--Working with Wet Whole Blood 19
     
    2.3.1 Is Your Choice of Assay Biologically Relevant in Blood? 19
     
    2.3.2 Working with Blood as a Matrix 20
     
    2.3.3 Allowing Analytes to Equilibrate Ex Vivo 21
     
    2.3.4 Bridging Between Venous Capillary Blood and the Role of Anticoagulants 22
     
    2.4 Tip 3--Working with Dried Whole Blood 24
     
    2.4.1 Dried Blood Spot Cards 24
     
    2.4.2 Volumetric Hematocrit Bias--Blood Viscosity 25
     
    2.4.3 Dried Blood is a Complicated Matrix 26
     
    2.4.4 Working with "Aged" Blood 26
     
    2.4.5 Temporal Extraction Bias or Degradation? 27
     
    2.5 Tip 4--Optimizing Extraction Efficiencies from VAMS 29
     
    2.5.1 Measuring Percentage Recovery from Mitra Samplers 30
     
    2.5.2 Extraction Conditions--Where to Start 31
     
    2.5.2.1 Consulting the Literature and Matching Physicochemical Properties 31
     
    2.5.2.2 Adapting Published DBS Methods 32
     
    2.5.2.3 Converting from a Wet (Whole Blood or Plasma) Method 32
     
    2.5.2.4 Starting from a Blank Canvas--What to Consider? 33
     
    2.5.2.5 Choice of Matrix 35
     
    2.5.3 Aqueous Extraction Conditions 36
     
    2.5.4 Organic Extraction Conditions 37
     
    2.5.5 Generic Extraction Conditions 39
     
    2.6 Conclusions 40
     
    References 41
     
    3 Preanalytical Considerations for Implementation of Microsampling Solutions 49
    Bradley B. Collier, Peyton K. Miesse, and Russell P. Grant
     
    3.1 Introduction 49
     
    3.2 Sample Matrices 50
     
    3.2.1 Venous Sample 51
     
    3.2.2 Capillary Blood 54
     
    3.2.3 Material Selection 62
     
    3.2.4 Dried Samples 62
     
    3.2.5 Conclusions 63
     
    3.3 Alternate Sample Acceptance Criteria 63
     
    3.4 Collection 65
     
    3.4.1 Device and Kit Components 66
     
    3.4.2 Training and Preparation 67
     
    3.4.3 Wound Generation 68
     
    3.4.4 Collecting Sample 70
     
    3.4.5 Post Collection Processing 72
     
    3.4.6 Conclusions 72
     
    3.5 Transportation and Sample Stability 73
     
    3.5.1 Specimen Matrix and Separation 73
     
    3.5.2 Storage Condition 74
     
    3.5.3 Measurement Technique 77
     
    3.5.4 Hematocrit Effects 79
     
    3.5.5 Conclusions 79
     
    3.6 Preanalytical Processing 80
     
    3.6.1 Separation of Plasma and Serum 80
     
    3.6.2 Sample Dilution 81
     
    3.6.3 Conclusions 82
     
    3.7 Overall Conclusions 82
     
    References 83
     
    4 Collection and Bioanalysis of Quantitative Microsamples: Technological Innovations and Practical Implications 93
    Regina