Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
17.01.2023
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
64
Maße (L/B/H)
22/15/0.5 cm
Gewicht
113 g
Sprache
Englisch
ISBN
978-620-5-63395-3
The 1, 4-thiazepine fused derivatives were synthesized by L-proline catalyzed one-pot mechanistic pathway. Though L-proline is being amphoteric molecule with both amine end carboxylic acid end, it worked as an enamine base for the catalysis. We aim to synthesize organic molecules with anti-cancer activity. This protocol provides a synthetic route for the efficient synthesis of 1, 4 -thiazepines. All the synthesized molecules were screened for the cytotoxicity studies. We have screened the synthesized 1, 4-thiazepines against to six cell lines, namely 'Pancreas (PANC1), Renal (ACHN), Colon (HCT116), Non-small cell lung (H460), Lung (CALUl) and Normal breast epithelium (MCF10A)' with two concentration 1miM and 10miM concentration levels.
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