Produktbild: Principles of Cloning

Principles of Cloning

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.09.2024

Herausgeber

Cibelli Jose

Verlag

Elsevier

Seitenzahl

600

Maße (L/B)

27.6/21.6 cm

Auflage

3. Auflage

Sprache

Englisch

ISBN

978-0-443-13460-9

Beschreibung

Portrait

Dr. Cibelli is Professor of Animal Biotechnology at Michigan State University. He heads the Cellular Reprogramming Laboratory in the Departments of Animal Science and Physiology since 2003. From 2010 to 2017 he was also the Scientific Director of LARCel, a laboratory of cellular reprogramming dedicated to generating human pluripotent cells under GMP conditions for preclinical studies in Andalucia, Spain. Dr. Cibelli is internationally recognized as one of the pioneers in the area of cellular reprogramming using oocyte-driven protocols. Dr. Cibelli together with his colleagues, were responsible for the generation of the world's first transgenic cloned calves, the first stem cells by nuclear transfer in bovine, the first embryonic stem cells by parthenogenesis in primates and the generation of the first cell line of iPSCs using oocyte factors alone. His work has been published un numerous scientific journals including Science, Nature Biotechnology, Nature Medicine, Nature Methods, PNAS, Cell Stem Cell and JAMA.

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.09.2024

Herausgeber

Cibelli Jose

Verlag

Elsevier

Seitenzahl

600

Maße (L/B)

27.6/21.6 cm

Auflage

3. Auflage

Sprache

Englisch

ISBN

978-0-443-13460-9

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  • Produktbild: Principles of Cloning
  • 1. Cloning History and Universal Principles

    Part I Basics
    2. Multiplying Embryos: Experimental Monozygotic Polyembryony in Mammals and its uses
    3. Artificial Activation of Mammalian Oocytes
    4. Nuclear Origins and Clone Phenotype
    5. Genetic and Phenotypic Similarity Among Members of Mammalian Clonal Sets

    Part II Methods
    6. Micromanipulation Techniques for Cloning
    7. Handmade Cloning
    8. Culture of Viable Mammalian Embryos In Vitro
    9. Pregnancy and Neonatal Care of SCNT Animals
    10. Donor Cell Type and Cloning Efficiency in Mammals
    11. Enhancing SCNT with Chromatin Remodeling Agents
    12. Cell Cycle Regulation in Cloning

    Part III Cloning by Species
    13. Amphibia
    14. Medaka Fish
    15. Zebrafish
    16. Goldfish
    17. Mice
    18. Rabbits
    19. Pigs
    20. Cows
    21. Dogs
    22. Equids
    23. Macaque Monkeys

    Part IV Complementary Technologies
    24. Genome Editing in Somatic Cells
    25. Targeted Chromosome Elimination from ES-Somatic Hybrid Cells

    Part V Applications
    26. Nuclear Transfer for Stem Cells
    27. Embryonic Stem Cell in Bovine (other species?)
    28. Commercial Applications of Cloning Technology
    29. Production of Recombinant Therapeutic Proteins
    30. Generation of Transgenic Domestic Species via Somatic Cell Nuclear Transfer
    31. Commercializing Genetically Engineered Cloned Cattle
    32. Cloning Endangered Species
    33. Genetically Engineered Pigs for Medicine

    Part VI Mechanisms
    34. Histone Methylation During Somatic Cell Nuclear Transfer
    35. Nuclear Transfer with Germ Cells: Germ Cell Cloning Contributes to current Understanding of Genomic Imprinting in Mammals
    36. Clone-Specific X-Linked Gene Repression Caused by Ectopic Xist Transcripts from the Active X Chromosome
    37. Cell Division and Nuclear Reprogramming
    38. Reprogramming Machinery of the Mouse Oocyte - Proteomic Analyses
    39. Biological Age of Cloned Animals
    40. Mitochondrial Inheritance in Cloned Animals
    41. Interspecies Somatic Cell Nuclear Transfer
    42. Epigenetics of Cloned Livestock Embryos and Offspring
    43. Role of iPSC-Producing Factors in Pre-Implantation Embryos
    44. Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos
    45. Genome Exchange in Human Oocytes

    Part VII Ethical, Regulatory and Legal Affairs
    46. Ethical Implications of Reproductive Cloning
    47. An Overview of the Regulatory Considerations for Animal Cloning in the USA
    48. Regulation and safety considerations of somatic cell nuclear transfer-cloned farm animals and their offspring used for food production - the European Union perspective
    49. Asian Regulatory Landscape on Animal Cloning
    50. South American Governmental guidelines for the production and commercialization of Cloned Animals

    Part VIII Cloning Outlook
    51. Somatic cell nuclear transfer: failures, successes, and the challenges ahead