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Produktbild: KRAS
Band 2797

KRAS Methods and Protocols

Aus der Reihe Methods in Molecular Biology

Fr. 276.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.04.2024

Abbildungen

XI, 365 p. 83 illus., 69 illus. in color.

Herausgeber

Andrew G. Stephen + weitere

Verlag

Springer Us

Seitenzahl

365

Maße (L/B/H)

26/18.3/2.6 cm

Gewicht

910 g

Sprache

Englisch

ISBN

978-1-07-163821-7

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.04.2024

Abbildungen

XI, 365 p. 83 illus., 69 illus. in color.

Herausgeber

Verlag

Springer Us

Seitenzahl

365

Maße (L/B/H)

26/18.3/2.6 cm

Gewicht

910 g

Sprache

Englisch

ISBN

978-1-07-163821-7

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: KRAS

  • KRAS as a therapeutic target.- The abundance of KRAS and RAS gene mutations in cancer.- Production of isotopically labeled KRAS4b.- Nucleotide Exchange on RAS Proteins using Hydrolysable and Non-Hydrolysable Nucleotides.- Crystallographic studies of KRAS in Complex with Small Molecules and RAS-binding Proteins.- Considerations around Structure-Based Drug Discovery for KRAS using DOCK.- Measurement of KRAS GTPase activity.- Affinity Measurement of Non-covalent Interactions of the covalent KRAS G12C GDP inhibitor MRTX849 to RAS Isoforms using Surface Plasmon Resonance.- 1D and 2D NMR for KRAS:ligand binding.- Luminescence based techniques for KRAS thermal stability monitoring.- MALDI-TOF mass spectrometry-based assay for measuring covalent target engagement of KRAS G12C inhibitors.- KRAS4b:RAF-1 Homogenous Time-Resolved Fluorescence Resonance Energy Transfer Assay for Drug Discovery.- Biophysical characterization of RAS-SOS Complexes by Native Mass Spectrometry.- Profiling complex RAS-effector interactions using NMR spectroscopy.- Probing RAS Function Using Monobody and NanoBiT Technologies.- Analysis of the guanine nucleotide-bound state of KRAS by ion-pair reversed-phase high-performance liquid chromatography.- Real-time monitoring of RAS activity using in vitro and in-cell NMR spectroscopy.- Studying RAS Interactions in live cells with BRET.- FLIM-FRET Protein-Protein Interaction Assay.- High-throughput cell-based screening of small molecule KRAS signaling inhibitors using a homogeneous time resolved fluorescence (HTRF) assay.- A method to conditionally measure target engagement at intracellular RAS and RAF complexes.- FLAG-KRAS4B as a model system for KRAS4B proteoform and PTM evaluation by mass spectrometry .- Creation of an isogenic H/N/KRAS-less mouse embryonic fibroblast cell line panel derived from a size sorted diploid clone.- Quality Control ofan Isogenic H/N/KRAS-less Mouse Embryonic Fibroblast Cell Line Panel.- A Facile Method to Append a Bio-ID Tag to Endogenous Mutant Kras Alleles.