Biomarkers and Therapeutical Targets for Prion Diseases

Giuseppe Legname earned his Doctor of Philosophy degree at the University of Warwick, UK. After a long spell in industry in the field of immunotherapy, he moved to the National Institute for Medical Research (NIMR), Medical Research Council in London, UK as a Research Associate. In 1999 he became Assistant Adjunct Professor, and later Associate Adjunct Professor, at the Institute for Neurodegenerative Diseases (IND), University of California at San Francisco, USA, under the direction of 1997 Nobel Laureate Professor Stanley B. Prusiner.

In 2006 he joined the faculty of the Scuola Internazionale Superiore di Studi Avanzati (SISSA) in Trieste, Italy, at the Department of Neuroscience. Currently he is Professor of Biochemistry in the same Department and Coordinator of the PhD Program in Molecular Biology.

The main focuses of his research program are the physiological function of the prion protein in mammals and the mechanisms of prion replication as well as the structural characterization of molecular determinants for prion infectivity.

Fabio Moda earned his Doctor of Philosophy degree in Translational and Molecular Medicine at the University of Milano-Bicocca, Italy. In 2022 he completed his specialization in Clinical Pathology and Clinical Biochemistry at the University of Pavia, Italy. Since 2006, he has been working at the Fondazione IRCCS Istituto Neurologico Carlo Besta in Milan. He is currently an Assistant Professor of Clinical Biochemistry and Clinical Molecular Biology in the Department of Medical Biotechnology and Translational Medicine at the University of Milan and also carries out research and clinical activities as a Biologist Manager at the Carlo Besta Neurological Institute. At the Besta Institute, he is in charge of the biosafety level 3 laboratory (BSL3), where he performs diagnostic tests on cerebrospinal fluids and biochemical analysis of brain tissues collected from patients with prion diseases and other dementias. His research primarily focuses on identifying novel disease biomarkers present in peripheral tissues, including the olfactory mucosa, urine, saliva, tears, and blood of patients with neurodegenerative disorders.