Sickle cell anemia is a hereditary blood disorder caused by a mutation in the ss-globin gene, leading to formation of abnormal hemoglobin called HbS.Under low oxygen conditions, HbS polymerizes, causing red blood cells to become sickle-shaped, rigid, and fragile.These abnormal cells have a short lifespan (10-20 days) and can block small blood vessels.Key features: Chronic hemolytic anemia. Painful vaso-occlusive crises. Recurrent infections (due to functional asplenia). Delayed growth and organ damage (spleen, kidneys, lungs, brain).
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