New Piperazine Derivatives: Biologic and Spectroscopic Study A new piperazine derivatives were synthesized. All compounds were characterized by NMR, FT-IR, Mass spectral data Second Edition
-
- Englisch ausgewählt
Fr. 81.90
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
02.03.2026
Verlag
LAP LAMBERT Academic PublishingSeitenzahl
96
Maße (L/B/H)
22/15/0.6 cm
Gewicht
161 g
Sprache
Englisch
ISBN
978-620-9-65245-5
A new piperazine derivatives: 2,2'-(piperazine-1,4-diyl)bis(N'-((Z)-2,4-dihydroxybenzylidene)acetohydrazide), 2.2'-(piperazine-1,4-diyl)bis (N'-((Z)-2-hydroxy-4-methoxybenzylidene)acetohydrazide) and 2.2'-(piperazine-1,4-diyl) bis N'-((Z)-1-(2-hydroxynaphthalen-1-yl) ethylidene) aceto hydrazide) were synthesized. The characterization of all compounds was characterized by NMR, FT-IR, Mass spectral data and elemental analysis. 1H and 13C shielding tensors of all compounds were calculated with GIAO/DFT/B3LYP/6-31 G(d) methods in DMSO. Molecular electrostatic potential surface and frontier orbital analysis were also carried out. HOMO-LUMO energy gap was calculated which allowed the calculation of relative reactivity descriptors like chemical hardness, chemical inertness, chemical potential, nucleophilicity and electrophilicity index of all compounds. Molecular docking studies of compounds were performed for Lanosterol-14a-demethylase (CYP51) enzyme (PDB ID: 3JUS). The microbiological effect of all compounds were tested against five human pathogenic bacteria and three fungal by using microdilution and disc diffusion methods.
Kundinnen und Kunden meinen
Verfassen Sie die erste Bewertung zu diesem Artikel
Helfen Sie anderen Kund*innen durch Ihre Meinung