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Produktbild: Drug Resistance in Gram-negative Bacteria
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Drug Resistance in Gram-negative Bacteria Therapies and Beyond

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Beschreibung

This book serves as a thorough resource that explores the complex mechanisms behind drug resistance in Gram-negative bacteria, the pitfalls of existing treatment strategies, and the new alternative therapeutic options arising. The book explores the molecular mechanisms behind drug resistance, including...

Beschreibung

This book serves as a thorough resource that explores the complex mechanisms behind drug resistance in Gram-negative bacteria, the pitfalls of existing treatment strategies, and the new alternative therapeutic options arising. The book explores the molecular mechanisms behind drug resistance, including β-lactamase production, efflux pumps, and biofilm development, while analyzing the clinical and environmental factors that facilitate their spread. Alongside traditional antibiotics, it discusses new developments in alternative treatment methods such as bacteriophage therapy, antimicrobial peptides, CRISPR technology, and vaccine development. The book also addresses surveillance tools, resistance gene tracking, and host-pathogen interactions by incorporating insights from molecular biology, genomics, and systems-based approaches. Written by specialists in microbiology and infectious diseases, this book provides an innovative viewpoint on grasping, addressing, and fighting Gram-negative bacterial resistance. It serves as an important asset for scientists, healthcare workers, public health experts, and graduate students engaged in research and policy regarding antimicrobial resistance.

Portrait

Dr. Minarul Islam is a researcher in medical sciences, microbiology, metagenomics, and infectious diseases, with a focus on host-microbe interactions, antibiotic resistance, and the molecular mechanisms that underpin health and illness. He received his Ph.D. in Medical Sciences from Jeonbuk National University in South Korea and is currently serve as a Research Professor in the Department of Food Science and Biotechnology at Gachon University in Seongnam, South Korea. His scientific interests include microbial genomics, gut microbiome research, antibiotic resistance, and the development of microbiome-based therapeutic approaches. His research and academic contributions aim to increase our understanding of microbial pathogenesis, medication resistance mechanisms, and developing ways to combating multidrug-resistant bacterial illnesses. He specializes in microbiological and molecular biology methods, drug resistance, metagenomics, and bioinformatics-based genomic analysis. He is a highly driven, analytical, and detail-oriented researcher with excellent critical thinking, problem-solving, and scientific communication abilities. He is capable of working independently and efficiently with interdisciplinary research teams to solve complicated biomedical problems. His work focuses on enhancing scientific understanding of microbial biology and disease causes, as well as developing novel, evidence-based ways to improving human health.

Dr. Md. Habibur Rahman is an internationally recognized medical scientist, registered pharmacist, and translational neuroscience researcher with multidisciplinary expertise spanning neuroscience, neuropharmacology, molecular biology, oxidative stress, neuroinflammation, biomarker discovery, and therapeutic development. He holds a Ph.D. in Medical Science and has established a strong research profile at the interface of molecular mechanisms, disease biology, pharmacological intervention, and clinical translation, with his primary research focused on dementia and neurodegenerative diseases, particularly Alzheimer’s disease, and the discovery of clinically relevant biomarkers, molecular targets, and precision diagnostic and therapeutic strategies. His extensive expertise encompasses gene-expression analysis, redox biology, neuroinflammatory signaling, molecular and cellular mechanisms of neurodegeneration, experimental pharmacology, and translational therapeutics, enabling him to bridge fundamental biomedical discoveries with clinically meaningful innovations. Dr. Rahman has received international recognition, including being ranked among the top 2% of scientists worldwide in Stanford University’s citation-based global ranking, reflecting the impact and international visibility of his scientific contributions. He is an active scientific leader, invited speaker, peer reviewer, and international collaborator, regularly contributing to global conferences, academic forums, multidisciplinary research initiatives, and the peer-review process for international scientific journals. His long-term research vision is to advance precision medicine in neurological disease through innovative biomarker discovery, therapeutic target identification, and the translation of molecular neuroscience into clinically actionable diagnostic and treatment strategies.

Prof. Dr. Rahima Begum is a researcher in Medical Science, Cellular and Molecular Biology, Microbiology, and Immunology, with a strong focus on health and disease. She earned her Ph.D. from Yonsei University, South Korea, and currently serves as an Assistant Professor in the Department of Microbiology at Gono Bishwabidyalay, Dhaka, Bangladesh. Her research interests encompass molecular mechanisms underlying health and disease, with particular emphasis on molecular hydrogen and its therapeutic potential, as well as the antioxidant and antibacterial properties of medicinal plants and plant-derived extracts. Her research also explores the potential application of natural bioactive compounds in combating oxidative stress, microbial infections, inflammation, and other disease-associated conditions. Dr. Rahima is passionate about interdisciplinary and collaborative research and is committed to developing innovative approaches to address emerging challenges in biomedical and health sciences. She applies her expertise in microbiology, molecular biology, immunology, and experimental research to investigate scientifically and clinically relevant problems. She is adaptable, detail-oriented, proactive, and capable of working effectively both independently and as part of multidisciplinary research teams. Her work is dedicated to advancing biomedical knowledge and contributing to improved health outcomes through innovative, evidence-based research.

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

24.02.2027

Abbildungen

III, 533 p. 57 illus., 56 illus. in color.

Herausgeber Md. Minarul Islam + weitere

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

24.02.2027

Abbildungen

III, 533 p. 57 illus., 56 illus. in color.

Herausgeber
Verlag Springer Singapore
Seitenzahl

533

Maße (B/H)

15.5/23.5 cm

Sprache

Englisch

ISBN

978-981-9288-38-0

Herstelleradresse

Springer Singapore
No. 12-2F 101 Business Park
47100 Puchong, Selangor D.E.
MY
Email: sdc-bookservice@springer.com
Telephone: +49 6221 3454301
Fax: +49 6221 3454229

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  • Produktbild: Drug Resistance in Gram-negative Bacteria
  • Part 1. Introduction to Drug resistance Bacteria and burden.- Chapter 1. Gram-negative bacteria: Structure, physiology, and clinical importance.- Chapter 2. Antibiotics and their mechanisms of action in treating Gram-negative bacterial infections.- Chapter 3. Molecular and Cellular Mechanisms of Antibiotic Resistance in Gram-Negative Bacteria.- Part 2. Mechanism of Drug Resistance.- Chapter 4. Virulence Factors and Their Association with Antimicrobial Resistance in Gram-Negative Pathogens.- Chapter 5. Surveillance and epidemiology of antimicrobial resistance in Gram-negative bacteria.- Chapter 6. Role of mobile genetic elements in acquisition and dissemination of antibiotic resistance.- Chapter 7. Pathophysiology and Diagnostic Approaches for MDR Gram-negative Infections.- Chapter 8. Genetic Basis and Phenotypic Expression of Antimicrobial Resistance.- Part 3. Treatment and Therapy options.- Chapter 9. Burden of Multidrug-Resistant Pathogens in Treated Infections.- Chapter 10. Strategies to address drug resistance in Gram-negative bacteria: combination therapy and drug repurposing.- Chapter 11. Anti-microbial stewardship to control the dissemination of drug resistance.- Chapter 12. Bacteriophage therapy: An alternative to antibiotics.- Chapter 13. Antimicrobial peptides and their potential to fight drug-resistant gram-negative bacterial infections.- Chapter 14. Nanotechnology, photodynamic therapy, and CRISPR/CAS technology in combating Gram-negative resistance.- Chapter 15. Immunotherapy and vaccines.- Chapter 16. Therapeutic strategies for managing infections caused by pathogenic biofilms.- Chapter 17. Advancements in New Antibiotics: Colistin, Cefiderocol, and Beyond for Gram-Negative Infections.