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Produktbild: Practice of Medicinal Chemistry

Practice of Medicinal Chemistry 3rd Edition

Aus der Reihe Academic Press

Fr. 179.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

August 2008

Abbildungen

Approx. 910 illustrations (900 in full color)

Herausgeber

Camille G. Wermuth

Verlag

Elsevier LTD, Oxford

Seitenzahl

982

Maße (L/B/H)

28.4/22.7/4.1 cm

Gewicht

2214 g

Auflage

3rd ed.

Sprache

Englisch

ISBN

978-0-12-374194-3

Beschreibung

Rezension

"A useful, authoritative discussion of the principles and practice of medicinal chemistry... the volume has a useful index, is well produced and is very reasonably priced."
- JOURNAL OF MEDICINAL CHEMISTRY

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

August 2008

Abbildungen

Approx. 910 illustrations (900 in full color)

Herausgeber

Camille G. Wermuth

Verlag

Elsevier LTD, Oxford

Seitenzahl

982

Maße (L/B/H)

28.4/22.7/4.1 cm

Gewicht

2214 g

Auflage

3rd ed.

Sprache

Englisch

ISBN

978-0-12-374194-3

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Die Leseprobe wird geladen.
  • Produktbild: Practice of Medicinal Chemistry
  • Biography

    Section Editors

    Contributors

    Preface to the First Edition

    Preface to the Second Edition

    Preface to the Third Edition

    Part I General Aspects of Medicinal Chemistry

    1. A History of Drug Discovery

    I. Introduction

    II. Two Hundred Years of Drug Discoveries

    III. Considerations on Recent Trends in Drug Discovery

    References

    2. Medicinal Chemistry: Definitions and Objectives, Drug Activity Phases, Drug Classification Systems

    I. Definitions and Objectives

    II. Drug Activity Phases

    III. Drug Classification Systems

    References

    3. Measurement and Expression of Drug Effects

    I. Introduction

    II. In Vitro Experiments

    III. Ex Vivo Experiments

    IV. In Vivo Experiments

    References

    4. Molecular Drug Targets

    I. Introduction

    II. Enzymes as Drug Targets

    III. Membrane Transporters as Drug Targets

    IV. Voltage-Gated Ion Channels as Drug Targets

    V. Non-Selective Cation Channels as Drug Targets

    VI. Direct Ligand-Gated Ion Channels (Receptors with Intrinsic Ion Channel)

    VII. Receptors with Intrinsic Enzyme Activity

    VIII. Receptors Coupled to Various Cytosolic Proteins

    IX. G-Protein-Coupled Receptors

    X. Nuclear Receptors As Drug Targets

    References

    5. Drug Targets, Target Identification, Validation and Screening

    I. Introduction

    II. Improving the Resolution of Disease Etiology

    III. Biopharmaceutical Therapies

    IV. Drug Target Identification

    V. Hit-to-Lead

    VI. Clinical Biomarkers

    VII. Conclusions

    References

    Part II Lead Compound Discovery Strategies

    6. Strategies in the Search for New Lead Compounds or Original Working Hypotheses

    I. Introduction

    II. First Strategy: Analog Design

    III. Second Strategy: Systematic Screening

    IV. Third Strategy: Exploitation of Biological Information

    V. Fourth Strategy: Planned Research and Rational Approaches

    VI. Conclusion

    References

    7. High-Throughput Screening and Drug Discovery

    I. Introduction

    II. Historical Background

    III. From Screen to Lead

    IV. Examples of Drugs Derived from Screening Leads

    V. Practical Application, Recent Example

    VI. Conclusion

    References

    8. Natural Products as Pharmaceuticals and Sources for Lead Structures

    I. Introduction

    II. The Importance of Natural Products in Drug Discovery and Development

    III. The Design of an Effective Natural-Products-Based Approach to Drug Discovery

    IV. Examples of Natural Products or Analogs as Drugs

    V. Future Directions in Natural Products as Drugs and Drug Design Templates

    VI. Summary

    References

    9. Biology Oriented Synthesis and Diversity Oriented Synthesis in Compound Collection Development

    I. Introduction

    II. Diversity Oriented Synthesis

    III. Biology Oriented Synthesis

    IV. Conclusion and Outlook

    References

    10. In Silico Screening: Hit Finding from Database Mining

    I. Introduction

    II. Representation of Chemical Structures

    III. Data Mining Methods

    IV. Database Searches

    V. Applications

    VI. Conclusion and Future Directions

    References

    11. Fragment-Based Drug Discovery

    I. Ligand-Protein Interactions: First Principles

    II. Status of Late 1990s Drug Discovery in the Pharmaceutical Industry

    III. What is FBDD?

    IV. Creation and Analysis of FBDD Libraries

    V. Nuclear Magnetic Resonance

    VI. X-ray Crystallography

    VII. Other Biophysical and Biochemical Screening Methods

    VIII. Methods for Fragment Hit Follow-Up

    IX. Trends for the Future

    References

    12. Lead-Likeness and Drug-Likeness

    I. Introduction

    II. Assessing " Drug-Likeness

    III. Selecting Better Leads: " Lead-Likeness

    IV. Conclusion

    References

    13. Web Alert: Using the Internet for Medicinal Chemistry

    I. Introduction

    II. Blogs

    III. Wikis

    IV. Compound Information

    V. Biological Properties of Compounds

    VI. Drug Information

    VII. Physical Chemical Information

    VIII. Prediction and Calculation of Molecular Properties

    IX.