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Produktbild: Amino Acids, Peptides and Proteins in Organic Chemistry
Band 2

Amino Acids, Peptides and Proteins in Organic Chemistry 5 Volume Set / Volume 2 - Modified Amino Acids, Organocatalysis and Enzymes

Aus der Reihe Amino Acids, Peptides and Proteins in Organic Chemistry. 5 Volume Set

Fr. 232.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

23.09.2009

Abbildungen

farbige Illustrationen, schwarz-weiss Illustrationen, Tabellen, schwarz-weiss

Herausgeber

Andrew B. Hughes

Verlag

Wiley-VCH

Seitenzahl

705

Maße (L/B/H)

25/18.1/3.8 cm

Gewicht

1488 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-527-32098-1

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

23.09.2009

Abbildungen

farbige Illustrationen, schwarz-weiss Illustrationen, Tabellen, schwarz-weiss

Herausgeber

Andrew B. Hughes

Verlag

Wiley-VCH

Seitenzahl

705

Maße (L/B/H)

25/18.1/3.8 cm

Gewicht

1488 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-527-32098-1

Herstelleradresse

Wiley-VCH GmbH
Boschstr. 12
69469 Weinheim
Deutschland
Email: cs-germany@wiley.com
Url: www.wiley-vch.de
Fax: +49 6201 606328

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  • Produktbild: Amino Acids, Peptides and Proteins in Organic Chemistry
  • PART I: Synthesis and Chemistry of Modified Amino Acids

     

    SYNTHESIS AND CHEMISTRY OF ALPHA, BETA-DIDEHYDROAMINO ACIDS

    Introduction

    Synthesis of DDAAs

    Reactions of DDAAs

    Experimental Procedures

    SYNTHESIS AND CHEMISTRY OF ALPHA-HYDRAZINO ACIDS

    Introduction

    Synthesis

    Chemistry

    Experimental Procedures

    HYDROXAMIC ACIDS: CHEMISTRY, BIOACTIVITY, AND SOLUTION- AND SOLID-PHASE SYNTHESIS

    Introduction

    Chemistry, Bioactivity, and Clinical Utility

    Solution-Phase Synthesis of Hydroxamic Acids

    Solid-Phase Synthesis of Hydroxamic Acids

    Experimental Procedures

    CHEMISTRY OF ALPHA-AMINOBORONIC ACIDS AND THEIR DERIVATIVES

    Introduction

    Synthesis of Alpha-Aminoboronic Acids

    Synthesis of Alpha-Aminoboronic Acid Derivatives

    Asymmetric Synthesis via Alpha-Haloalkylboronic Esters

    Synthesis of Glycine Alpha-Aminoboronic Acids

    Synthesis of Proline Alpha-Aminoboronic Acids

    Synthesis of Alanine Alpha-Aminoboronic Acids

    Synthesis of Ornithine Alpha-Aminoboronic Acids

    Synthesis of Arginine Alpha-Aminoboronic Acids

    Synthesis of Phenethyl Peptide Boronic Acids

    Synthesis via Zirconocene Species

    Synthesis and Activity of Amine-Carboxyboranes and their Derivatives

    Synthesis of Boron Analogs of Phosphonoacetates

    CHEMISTRY OF AMINOPHOSPHONIC ACIDS AND PHOSPHONOPEPTIDES

    Introduction

    Physical/Chemical Properties and Analysis

    Synthesis of Alpha-Aminophosphonic Acids

    Synthesis of Beta-Aminophosphonates

    Synthesis of Gamma-Aminophosphonates and Higher Homologs

    Phosphono- and Phosphinopeptides

    Remarks on the Practical Utility of Aminophosphonates

    Experimental Procedures

    CHEMISTRY OF SILICON-CONTAINING AMINO ACIDS

    Introduction

    Synthesis of Silicon-Containing Amino Acids

    Reactions of Silicon-Containing Amino Acids

    Bioactive Peptides Incorporating Silicon-Substituted Amino Acids

    Experimental Procedures

    PART II: Amino Acid Organocatalysis

     

    CATALYSIS OF REACTIONS BY AMINO ACIDS

    Introduction

    Aldol Reaction

    Mannich Reaction

    Alpha-Amination Reaction

    Michael Reaction

    Morita-Baylis-Hillman Reactions and their Aza Counterpart

    Miscellaneous Amino Acid-Catalyzed Reactions

    Sustainability of Amino Acid Catalysis

    Experimental Procedures

     

    PART III: Enzymes

     

    PROTEASES AS POWERFUL CATALYSTS FOR ORGANIC SYNTHESIS

    Enzyme Biocatalysis

    Proteolytic Enzymes: Mechanisms and Characteristics

    Proteases as Process Catalysts

    Proteases in Organic Synthesis

    Peptide Synthesis

    SEMISYNTHETIC ENZYMES

    Usefulness of Semisynthetic Enzymes

    Natural Protein Biosynthesis

    Sense Codon Reassignment

    Missense Suppression

    Evolving the Orthogonal aaRS/tRNA Pair

    Nonsense Suppression

    Mischarging of rRNA by Ribozyme

    Evolving the Orthogonal Ribosome/mRNA Pair

    Frame-Shift Suppression

    Noncanonical Base Pairs

    Chemical Ligation

    Inteins

    EPL

    Post-Transitional Chemical Modification

    Examples of Semisynthetic Enzymes

    CATALYSIS BY PEPTIDE-BASED ENZYME MODELS

    Introduction

    Peptide Models of Hydrolytic Enzymes

    Peptide Models of Heme Proteins

    SUBSTRATE RECOGNITION

    Recognition, Specificity, Catalysis, Inhibition, and Linguistics

    Serine Proteinases

    Cysteine Proteinases

    Glycoside Hydrolases

    Protein Kinases

    aaRSs

    Lipases

    PROTEIN RECOGNITION

    General Introduction

    Nature of Protein Interfaces

    Affinity of Protein Interactions

    Measuring Protein Interactions

    Coupled Folding and Binding

    Regulation of Interactions by PTMs

    Engineering and Inhibiting Protein-Protein Interactions

    MAMMALIAN PEPTIDE HORMONES: BIOSYNTHESIS AND INHIBITION

    Introduction

    Mammalian Peptide Hormones

    Biosynthesis of Peptide Hormones

    Inhibition of Biosynthesis

    INSECT PEPTIDE HORMONES

    Introductin

    Structure and Biosynthesis of Insect Peptide Hormones

    Proctolin

    Sex Peptide

    A-Type Allatostatins

    CRF-Related DHs

    Insect Peptide Hormones and Insect Control

    PLANT PEPTIDE SIGNALS

    Introduction

    Defense-Related Peptides

    Peptides Involved in Growth and Development

    Peptides Involved in Self-Recognition

    Methods in Plant Regulatory Peptide Research

    NONRIBOSOMAL PEPTIDE SYNTHESIS

    Introduction

    NRPs

    NRP Synthetase Domains

    PPTases

    Experimental Strategies for NRPS Investigations

    Non-NRPs