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Produktbild: Amino Acids, Peptides and Proteins in Organic Chemistry
Band 4

Amino Acids, Peptides and Proteins in Organic Chemistry 5 Volume Set / Volume 4 - Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis

Aus der Reihe Amino Acids, Peptides and Proteins in Organic Chemistry. 5 Volume Set

Fr. 236.00

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

18.03.2011

Abbildungen

Tabellen, schwarz-weiss, farbige Illustrationen, schwarz-weiss Illustrationen

Herausgeber

Andrew B. Hughes

Verlag

Wiley-VCH

Seitenzahl

552

Maße (L/B/H)

24.6/17.9/3.3 cm

Gewicht

1136 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-527-32103-2

Beschreibung

Portrait

Andrew Hughes is a reader and Head of the Department of Chemistry, La Trobe University, Melbourne, Australia. He obtained his degrees from the University of Western Australia before taking up post-doctoral appointments at the University of Cambridge starting 1989. After three years working with Professor Andrew Holmes, he joined Professor Steven Ley´s group. While at Cambridge he was appointed the Shell Research Fellow at Robinson College. His interests lie in the general field of asymmetric synthesis and methodology, with a recent focus on amino acid chemistry.

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

18.03.2011

Abbildungen

Tabellen, schwarz-weiss, farbige Illustrationen, schwarz-weiss Illustrationen

Herausgeber

Andrew B. Hughes

Verlag

Wiley-VCH

Seitenzahl

552

Maße (L/B/H)

24.6/17.9/3.3 cm

Gewicht

1136 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-527-32103-2

Herstelleradresse

Wiley-VCH GmbH
Boschstrasse 12
69469 Weinheim
DE
product_safety@wiley.com

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  • Produktbild: Amino Acids, Peptides and Proteins in Organic Chemistry
  • PROTECTION REACTIONS

    General Considerations

    Alpha-Amino Protection (Nalpha-Protection)

    Carboxy Protection

    Side Chain Protection

    Photocleavable Protections

    Conclusions

    Experimental Procedures

     

    PART I: Amino Acid-Based Peptidomimetics

     

    THE HUISGEN CYCLOADDITION IN PEPTIDOMIMETIC CHEMISTRY

    Introduction

    Huisgen [2+3] Cycloaddition Between Azides and Acetylenes

    Mechanistic Consideration for the Cu-Huisgen and Ru-Huisgen Cycloaddition

    Building Blocks for the Synthesis of TriazoleModified Peptidomimetics

    Cyclic Triazole Peptidomimetics

    Acylic Triazole Peptidomimetics

    Useful Experimental Procedures

     

    RECENT ADVANCES IN BETA-STRAND MIMETICS

    Introduction

    Macrocyclic Peptidomimetics

    Acyclic Compounds

    Aliphatic and Aromatic Carbocycles

    Ligands Containing One Ring with One Heteroatom (N)

    Ligands Containing One Ring or Multiple Rings with One Heteroatom (O,S)

    Ligands Containing One Ring with Two Heteroatoms (N,N)

    Ligands Containing One Ring with Two Heteroatoms (N,S) or Three Heteroatoms (N,N,S or N,N,N)

    Ligands Containing Two Rings with One Heteroatom (N or O)

    Ligands Containing Two Rings with Two or Three Heteroatoms (N,N or N,S or N,N,N)

    Conclusions

     

    PART II: Medicinal Chemistry of Amino Acids

     

    MEDICINAL CHEMISTRY OF ALPHA-AMINO ACIDS

    Introduction

    Glutamic Acid

    Conformational Restriction

    Bioisosterism

    Structure-Activity-Studies

    Conclusions

     

    MEDICINAL CHEMISTRY OF ALICYCLIC BETA-AMINO ACIDS

    Introduction

    Five-Membered Alicyclic Beta-Amino Acids

    Six-Membered Alicyclic Beta-Amino Acids

     

    MEDICINAL CHEMISTRY OF ALPHA-HYDROXY-BETA-AMINO ACIDS

    Introduction

    Alpha-Hydroxy-Beta-Amino Acids

    Antibacterial Agents

    Inhibitors of Aminopeptidases

    Aspartyl Proteases Inhibitors

    Paclitaxel and its Derivatives

     

    PEPTIDE DRUGS

    Lights and Shades of Peptide and Protein Drugs

    Peptide Drugs Available on the Market

    Approved Peptides in Oncology

    Antimicrobial Peptides

    Perspectives

     

    ORAL BIOAVAILABILITY OF PEPTIDE AND PEPTIDOMIMETIC DRUGS

    Introduction

    Fundamental Considerations of Intestinal Absorption

    Barriers Limiting Oral Peptide/Peptidomimetic Drug Bioavailability

    Strategies to Improve Oral Bioavailability of Peptide-Based Drugs

    Conclusions

     

    ASYMMETRIC SYNTHESIS OF BETA-LACTAMS VIA THE STAUDINGER REACTION

    Introduction

    Staudinger Reaction

    Influence of the Geometry of the Imine on Stereoselectivity in the Reaction

    Influence of the Polarity of the Solvent on Stereoselectivity of the Reaction

    Influence of the Isomerization of the Imine Prior to its Nucleophilic Attack onto the Ketene Stereoselectivity in the Reaction

    Influence of the Order of Addition of the Reactants to the Reaction

    Influence of Chiral Substituents on the Stereoselectivity of the Reaction

    Asymmetric Induction from the Imine Component

    Asymmetric Induction from the Ketene Component

    Double Asymmetric Cycloinduction

    Influence of Catalysts on the Stereoselectivity of the Reaction

    Concludings

     

    ADVANCES IN N- AND O-GLYCOPEPTIDE SYNTHESIS - A TOOL TO STUDY CLYCOSYLATION AND DEVELOP NEW THERAPEUTICS

    Introduction

    Synthesis of O-Glycopeptides

    Synthesis of N-Glycopeptides

     

    RECENT DEVELOPMENTS IN NEOGLYCOPEPTIDE SYNTHESIS

    Introduction

    Neoglycoside and Neoglycopeptide Synthesis

    Protein Side-Chain Modifications

    Cu(I)-Catalyzed Azide-Alkyne "Click" Cycloaddition

    Cross-Metathesis

    Application of Neoglycopeptides as Synthetic Vaccines

    Enzymatic, Molecular and Cell Biological Techniques

     

    PART III: Amino Acids in Combinatorial Synthesis

     

    COMBINATORIAL/LIBRARY PEPTIDE SYNTHESIS

    Introduction

    High-Throughput Synthesis of Peptides

    Synthesis of Peptide Arrays

    Peptide Libraries

    Future of Peptide Libraries

    Synthetic Protocols

     

    PHAGE-DISPLAYED COMBINATORIAL PEPTIDES

    Introduction

    Conclusions

     

    DESIGNING NEW PROTEINS

    Introduction

    Protein Design Methods

    Protocol for Protein Design

    Conclusions

     

    AMINO ACID-BASED DENDRIMERS

    Introduction

    Peptide Dendrimer Synthesis: Divergent and Convergent Approaches

    Applications of Peptide Dendrimers

    Conclusions