Metabolism, Pharmacokinetics and Toxicity of Functional Groups Impact of the Building Blocks of Medicinal Chemistry on ADMET
Fr. 234.00
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Gebundene Ausgabe
Erscheinungsdatum
09.04.2010
Herausgeber
Dennis A. SmithVerlag
RSC PublishingSeitenzahl
544
Maße (L/B/H)
24.3/16.4/3.5 cm
Gewicht
937 g
Sprache
Englisch
ISBN
978-1-84973-016-7
This outstanding book provides insight into the metabolism, pharmacokinetics and toxicity (ADMET) of chemicals by dividing the subject into functional groups. Following a description of chemical space and general ADMET in a unique way, by referring to actual chemical structures (functional groups) which even influence the molecules, they are incorporated into, in a specific manner. Many of the groupings are characterise the pharmacology of the drugs and are essential for particular activity; they are also a major influence in changing ADMET characteristics. These changes follow a pattern, thus allowing medicinal chemists to understand likely changes and how these can be overcome. Each chapter describes drugs containing the group, why the group is there and the physiochemical properties of a functional group before detailing the ADMET issues. In addition prodrugs and biosioteres are described where possible which may give alternative ADMET outcomes. The final chapter looks at future needs in terms of chemistry and ADMET understanding. Written by a team of scientists from Pfizer the book will appeal to postgraduate medicinal chemists and those working in industry.
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