Chemical Synthesis of Nucleoside Analogues
-
Form:Einzelkauf Download
-
Sprache:Englisch
-
eBook Format:PDF
- PDF Fr. 138.00 ausgewählt
- ePUB Fr. 138.00
Fr. 138.00
inkl. gesetzl. MwSt.Beschreibung
Produktdetails
Format
Kopierschutz
Ja
Family Sharing
Nein
Text-to-Speech
Nein
Erscheinungsdatum
12.02.2013
Herausgeber
Pedro MerinoVerlag
PolitySeitenzahl
912 (Printausgabe)
Dateigröße
8709 KB
Auflage
1. Auflage
Sprache
Englisch
EAN
9781118498170
Compiles current tested and proven approaches to
synthesize novel nucleoside analogues
Featuring contributions from leading synthetic chemists from
around the world, this book brings together and describes tested
and proven approaches for the chemical synthesis of common families
of nucleoside analogues. Readers will learn to create new
nucleoside analogues with desired therapeutic properties by using a
variety of methods to chemically modify natural nucleosides,
including:
* Changes to the heterocyclic base
* Modification of substituents at the sugar ring
* Replacement of the furanose ring by a different carbo- or
heterocyclic ring
* Introduction of conformational restrictions
* Synthesis of enantiomers
* Preparation of hydrolitically stable C-nucleosides
Chemical Synthesis of Nucleoside Analogues covers all the
major classes of nucleosides, including pronucleotides,
C-nucleosides, carbanucleosides, and PNA monomers which have shown
great promise as starting points for the synthesis of nucleoside
analogues. The book also includes experimental procedures for key
reactions related to the synthesis of nucleoside analogues,
providing a valuable tool for the preparation of a number of
different compounds.
Throughout the book, chemical schemes and figures help readers
better understand the chemical structures of nucleoside analogues
and the methods used to synthesize them. Extensive references serve
as a gateway to the growing body of original research studies and
reviews in the field.
Synthetically modified nucleosides have proven their value as
therapeutic drugs, in particular as antiviral and antitumor agents.
However, many of these nucleoside analogues have undesirable side
effects. With Chemical Synthesis of Nucleoside Analogues as
their guide, researchers have a new tool for synthesizing a new
generation of nucleoside analogues that can be used as therapeutic
drugs with fewer unwanted side effects.
synthesize novel nucleoside analogues
Featuring contributions from leading synthetic chemists from
around the world, this book brings together and describes tested
and proven approaches for the chemical synthesis of common families
of nucleoside analogues. Readers will learn to create new
nucleoside analogues with desired therapeutic properties by using a
variety of methods to chemically modify natural nucleosides,
including:
* Changes to the heterocyclic base
* Modification of substituents at the sugar ring
* Replacement of the furanose ring by a different carbo- or
heterocyclic ring
* Introduction of conformational restrictions
* Synthesis of enantiomers
* Preparation of hydrolitically stable C-nucleosides
Chemical Synthesis of Nucleoside Analogues covers all the
major classes of nucleosides, including pronucleotides,
C-nucleosides, carbanucleosides, and PNA monomers which have shown
great promise as starting points for the synthesis of nucleoside
analogues. The book also includes experimental procedures for key
reactions related to the synthesis of nucleoside analogues,
providing a valuable tool for the preparation of a number of
different compounds.
Throughout the book, chemical schemes and figures help readers
better understand the chemical structures of nucleoside analogues
and the methods used to synthesize them. Extensive references serve
as a gateway to the growing body of original research studies and
reviews in the field.
Synthetically modified nucleosides have proven their value as
therapeutic drugs, in particular as antiviral and antitumor agents.
However, many of these nucleoside analogues have undesirable side
effects. With Chemical Synthesis of Nucleoside Analogues as
their guide, researchers have a new tool for synthesizing a new
generation of nucleoside analogues that can be used as therapeutic
drugs with fewer unwanted side effects.
Noch keine Bewertungen vorhanden
Verfassen Sie die erste Bewertung zu diesem Artikel
Helfen Sie anderen Kundinnen und Kunden durch Ihre Meinung.