Molecular Targets in Protein Misfolding and Neurodegenerative Disease
Fr. 102.90
inkl. gesetzl. MwSt.Beschreibung
Produktdetails
Format
ePUB 3
Kopierschutz
Nein
Family Sharing
Nein
Text-to-Speech
Ja
Erscheinungsdatum
07.10.2014
Verlag
Elsevier Science & Techn.Seitenzahl
314 (Printausgabe)
Sprache
Englisch
EAN
9780128004999
Aimed at "drug discoverers" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.
- Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
- Provides a "drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
- Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
- Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
- Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets
- Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
- Provides a "drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
- Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
- Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
- Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets
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