Beschreibung
Produktdetails
Format
Kopierschutz
Ja
Family Sharing
Nein
Text-to-Speech
Nein
Erscheinungsdatum
13.10.2009
Herausgeber
Peter ScottVerlag
John Wiley & Sons IncSeitenzahl
706 (Printausgabe)
Dateigröße
24809 KB
Auflage
1. Auflage
Sprache
Englisch
EAN
9780470749050
Linker design is an expanding field with an exciting future in
state-of-the-art organic synthesis. Ever-increasing numbers of
ambitious solution phase reactions are being adapted for
solid-phase organic chemistry and to accommodate them, large
numbers of sophisticated linker units have been developed and are
now routinely employed in solid-phase synthesis.
Linker Strategies in Solid-Phase Organic Synthesis guides
the reader through the evolution of linker units from their genesis
in solid-supported peptide chemistry to the cutting edge diversity
linker units that are defining a new era of solid phase
synthesis. Individual linker classes are covered in easy to
follow chapters written by international experts in their
respective fields and offer a comprehensive guide to linker
technology whilst simultaneously serving as a handbook of synthetic
transformations now possible on solid supports. Topics include:
* the principles of solid phase organic synthesis
* electrophile and nucleophile cleavable linker units
* cyclative cleavage as a solid phase strategy
* photocleavable linker units
* safety-catch linker units
* enzyme cleavable linker units
* T1 and T2 -versatile triazene linker groups
* hydrazone linker units
* benzotriazole linker units
* phosphorus linker units
* sulfur linker units
* selenium and tellurium linker units
* sulfur, oxygen and selenium linker units cleaved by radical
processes
* silicon and germanium linker units
* boron and stannane linker units
* bismuth linker units
* transition metal carbonyl linker units
* linkers releasing olefins or cycloolefins by ring-closing
metathesis
* fluorous linker units
* solid-phase radiochemistry
The book concludes with extensive linker selection tables,
cataloguing the linker units described in this book according to
the substrate liberated upon cleavage and conditions used to
achieve such cleavage, enabling readers to choose the right linker
unit for their synthesis.
Linker Strategies in Solid-Phase Organic Synthesis is an
essential guide to the diversity of linker units for organic
chemists in academia and industry working in the broad areas of
solid-phase organic synthesis and diversity oriented synthesis,
medicinal chemists in the pharmaceutical industry who routinely
employ solid-phase chemistry in the drug discovery business, and
advanced undergraduates, postgraduates, and organic chemists with
an interest in leading-edge developments in their field.
state-of-the-art organic synthesis. Ever-increasing numbers of
ambitious solution phase reactions are being adapted for
solid-phase organic chemistry and to accommodate them, large
numbers of sophisticated linker units have been developed and are
now routinely employed in solid-phase synthesis.
Linker Strategies in Solid-Phase Organic Synthesis guides
the reader through the evolution of linker units from their genesis
in solid-supported peptide chemistry to the cutting edge diversity
linker units that are defining a new era of solid phase
synthesis. Individual linker classes are covered in easy to
follow chapters written by international experts in their
respective fields and offer a comprehensive guide to linker
technology whilst simultaneously serving as a handbook of synthetic
transformations now possible on solid supports. Topics include:
* the principles of solid phase organic synthesis
* electrophile and nucleophile cleavable linker units
* cyclative cleavage as a solid phase strategy
* photocleavable linker units
* safety-catch linker units
* enzyme cleavable linker units
* T1 and T2 -versatile triazene linker groups
* hydrazone linker units
* benzotriazole linker units
* phosphorus linker units
* sulfur linker units
* selenium and tellurium linker units
* sulfur, oxygen and selenium linker units cleaved by radical
processes
* silicon and germanium linker units
* boron and stannane linker units
* bismuth linker units
* transition metal carbonyl linker units
* linkers releasing olefins or cycloolefins by ring-closing
metathesis
* fluorous linker units
* solid-phase radiochemistry
The book concludes with extensive linker selection tables,
cataloguing the linker units described in this book according to
the substrate liberated upon cleavage and conditions used to
achieve such cleavage, enabling readers to choose the right linker
unit for their synthesis.
Linker Strategies in Solid-Phase Organic Synthesis is an
essential guide to the diversity of linker units for organic
chemists in academia and industry working in the broad areas of
solid-phase organic synthesis and diversity oriented synthesis,
medicinal chemists in the pharmaceutical industry who routinely
employ solid-phase chemistry in the drug discovery business, and
advanced undergraduates, postgraduates, and organic chemists with
an interest in leading-edge developments in their field.
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